Alcohol: The Forgotten Drug of Abuse

Parents have critical role in preventing teen drinking

Source:

University of Adelaide

Summary:

Fewer Australian teenagers are drinking alcohol but more needs to be done to curb the drinking habits of Aussie students, based on the findings of the latest study.

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Fewer Australian teenagers are drinking alcohol but more needs to be done to curb the drinking habits of Aussie students, based on the findings of the latest study by Adelaide researchers.

The results of the study, now published in the journal BMC Public Health, provide a snapshot of the prevalence of alcohol consumption among students, and the factors that most influence their drinking behaviour. This research has been supported by Cancer Council SA and SA Government.

"Harmful alcohol use is a serious problem in Australia, and drinking patterns are often first set in adolescence," says lead author Jacqueline Bowden, behavioural scientist and Manager of Population Health Research at SAHMRI, and researcher with the School of Psychology, University of Adelaide.

"With alcohol contributing to four of the top five causes of death in young people, and a leading cause of cancer in our community, it's important for us to better understand drinking behaviour among young people so we can help to prevent or delay it.

"One of the major messages from our study is that parents have more influence on their teenagers' decisions regarding alcohol than they probably realise. Parental behaviour and attitudes towards alcohol really do make a difference, and can help prevent children from drinking at an early age."
The study found:

• By age 16, most students had tried alcohol
• A third of students reported that they drank alcohol at least occasionally
• Only 28% of students were aware of a link between alcohol and cancer
• Across all ages, students were less likely to drink if their parents showed disapproval of underage drinking
• Those aged 14-17 were less likely to drink if they knew about the link between alcohol and cancer
• Smoking and approval of drinking from friends were more likely to result in drinking
• Once young people have become regular drinkers, the main predictor for drinking is the perceived availability of alcohol
• Cashed up students are more likely to drink.

Lincoln Size, Chief Executive Cancer Council SA, says: "The evidence is clear that alcohol use is a cause of cancer. Any level of alcohol consumption increases the risk of developing an alcohol-related cancer; the level of risk increases in line with the level of consumption.

"This latest evidence highlights the need to educate young people about the consequences of alcohol consumption and for parents to demonstrate responsible drinking behaviour. We need to get the message through that what may be considered harmless fun actually has lifelong consequences.

"We know that alcohol causes cancers of the mouth, pharynx, larynx, esophagus, bowel in men and breast among women. There is also probable evidence that alcohol increases the risk of bowel cancer in women, and liver cancer.

Ms Bowden says we need to address the issue of supply to teenagers. "Many parents believe providing their children with alcohol in the safe environment of their home teaches them to drink responsibly. However, the weight of evidence suggests that this increases consumption, and is not recommended.

"Our results also found that those adolescents who thought they could buy alcohol easily were more likely to drink regularly. The issue of availability -- including price -- and marketing of alcohol in the community is a major hurdle to be overcome.

"Alcohol is more affordable in Australia than it has been in the past 30 years, and the number of premises selling alcohol in Australia has increased substantially in the past 15 years. Throw advertising and sports sponsorship into the mix and we have some very strong messages that alcohol is the norm," Ms Bowden says.

"Our evidence shows that that parents have a significant and substantial role to play, to help their kids develop a healthier relationship with alcohol early. Parents can set the boundaries and create clear expectations."
Ms Bowden says parents should:

• Discuss alcohol use with their children, and the fact that not everyone drinks
• Get to know upcoming activities, such as parties, and set expectations for behaviour
• Reconsider drinking in front of children, as most alcohol is consumed by adults at home
• Have alcohol-free events
• Avoid binge drinking
• Don't buy alcohol for adolescents or provide it at parties.

"We often forget that alcohol is the most widely used recreational drug in Australia and has an enormous cost on families. It is important that parents set the right example," Ms Bowden says.

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Story Source:
Materials provided by University of Adelaide.

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New drug can restore memories in mice

Cortical tissue with plaques stained in blue, and astrocytes responding to drug treatment in red. NeuroscienceNews.com image is credited to the researchers.

Source: Yale.
A new drug can restore memories and connections between brain cells in mice with a model of Alzheimer’s disease, a new Yale-led study suggests.

“The drug completely erased evidence of Alzheimer’s synapse damage and memory loss in mouse models of the disease,” said Stephen Strittmatter, the Vincent Coates Professor of Neurology and senior author of the study appearing July 5 in the journal Cell Reports.

Researchers such as Strittmatter have made significant inroads into understanding the biology of Alzheimer’s disease, but identifying effective and safe treatments has been difficult. It is known that amyloid-beta peptides, the hallmark of Alzheimer’s, couple with prion protein at the surface of brain cells and transmit damaging instructions to the interior of the cell. Yale researchers had previously identified a protein on the cell membrane — metabotropic glutamate receptor 5 or mGluR5 — as the gateway that helps transmit damage from the coupling.

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Previous attempts had been made to target mGluR5, but most drugs also disrupt signaling of glutamate, the most common neurotransmitter in the human brain. The new compound, Silent Allosteric Modulation or SAM (BMS 984923), was created by Bristol Myers Squibb as part of its effort to treat schizophrenia. The drug does not restrict neurotransmitter signaling in culture tissue or living mice, the study found. After four weeks of treatment, memory and synapses linking brain cells had been restored in mice with a model of Alzheimer’s.

“The drug does not destroy plaques associated with Alzheimer’s, but allows them to co-exist with neurons,” Strittmatter said

Yale researchers say the next step is to prepare for preliminary trials of the drug’s effects on humans.
Primary funding for the research comes from the National Institutes of Health.   

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The brain, this three-pound mass of gray and white matter, sits at the center of all human activity—you need it to drive a car, to enjoy a meal, to breathe, to create an artistic masterpiece, and to enjoy everyday activities. In brief, the brain regulates your body’s basic functions; enables you to interpret and respond to everything you experience; and shapes your thoughts, emotions, and behavior.

The brain is made up of many parts that all work together as a team. Different parts of the brain are responsible for coordinating and performing specific functions. Drugs can alter important brain areas that are necessary for life-sustaining functions and can drive the compulsive drug abuse that marks addiction.

Key brain areas affected by drug abuse include:

The brain stem, which controls basic functions critical to life, such as heart rate, breathing, and sleeping.

The cerebral cortex, which is divided into areas that control specific functions.

Different areas process information from our senses, enabling us to see, feel, hear, and taste. The front part of the cortex, the frontal cortex or forebrain, is the thinking center of the brain; it powers our ability to think, plan, solve problems, and make decisions.

The limbic system, which contains the brain’s reward circuit. It links together a number of brain structures that control and regulate our ability to feel pleasure. Feeling pleasure motivates us to repeat behaviors that are critical to our existence. The limbic system is activated by healthy, life-sustaining activities such as eating and socializing— but it is also activated by drugs of abuse. In addition, the limbic system is responsible for our perception of other emotions, both positive and negative, which explains the mood-altering properties of many drugs.

How do drugs work in the brain?

Drugs are chemicals that affect the brain by tapping into its communication system and interfering with the way neurons normally send, receive, and process information. Some drugs, such as marijuana and heroin, can activate neurons because their chemical structure mimics that of a natural neurotransmitter. This similarity in structure “fools” receptors and allows the drugs to attach onto and activate the neurons. Although these drugs mimic the brain’s own chemicals, they don’t activate neurons in the same way as a natural neurotransmitter, and they lead to abnormal messages being transmitted through the network.

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