Trump: Insomniac in chief?

Donald Trump is known for his lack of sleep (tweeting in the small hours of the morning). Problem is he's got a growing nation of insomniacs, frightened awake at his erratic, upsetting behavior. What is sleep and why do we need it to maintain health? This article from the Dana Foundation gives an overview. Learn about brain essentials in our book, Healing the Brain.

A good deal of progress has been made recently in understanding why sleep is so important. Recent studies have shown that both acute sleep deprivation (staying awake all night) and chronic sleep restriction (sleeping only a few hours/night for 1-2 weeks) impair many cognitive functions, from vigilance and attention to speech and humor appreciation. 

We also know that it may take more than one or two days to recover after chronic sleep loss, so oversleeping during the week-end may not be enough, if the accumulated sleep debt is large. There is also strong evidence that sleep need varies significantly among individuals, although why some of us can function well with much less sleep than others remains unclear. Other studies show that a night of sleep benefits the acquisition of new information the next day (new learning during sleep, instead, remains largely a dream). 

Sleep also leads to the consolidation and integration of memories, both declarative memories - those one can recollect consciously, such as lists of words or associations between pictures and places, as well as non-declarative memories such as perceptual and motor skills. These experimental results fit the common observation that after intensive learning, say practicing a piece over and over on the guitar, performance often becomes fluid only after a night of sleep. It is likely that when we learn and repeatedly activate certain brain circuits, many synapses end up strengthening, not only when you play the right notes well, but also when you do it badly, or fumble other notes. The result is that, while by practicing you get better and better on average, your performance remains a bit noisy and variable. 

After sleep, it is as if the core of what you learned had been preserved, whereas the chaff is eliminated - that is, sleep seems to notch-up the signal-to-noise ratio. Something similar may happen also with declarative memories: in the face of the hundreds of thousands of scenes we encounter in waking life, memory is particularly effective at gist extraction, where the details (the noise) may be lost, but the main point of what happened to us (the signal) is preserved. So far, it seems that the memory benefits of sleep, especially for declarative memories, are due primarily to NREM sleep, but in some instances REM sleep or a combination of NREM-REM cycles may also play a role. One should not forget that memories can also consolidate during wake. Moreover, to some extent sleep helps memory consolidation simply because it reduces the interference caused by later memory traces.

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Trump Watch: Swatiskas, Slurs, Hate Epic Rise in Our Schools

The Southern Poverty Law Center has documented an alarming rise in hate crimes and language in our schools post-Trump. These incidents appear in The Trump Effect, just published by the SPLC. Read them and support A Thousand Moms' new publishing effort, Healing the Brain.

“Since the election, every single secondary school in our district has had issues with racist, xenophobic or misogynistic comments cropping up. In the week since the election, I have personally had to deal with the following issues: 1) Boys inappropriately grabbing and touching girls, even after they said no (this never happened until after the election); 2) White students telling their friends who are Hispanic or of color that their parents are going to be deported and that they would be thrown out of school; 3) White students going up to students of color who are total strangers and hurling racial remarks at them, such as, ‘Trump is going [to] throw you back over the wall, you know?’ or ‘We can’t wait until you and the other brownies are gone’; 4) The use of the n-word by white students in my class and in the hallway. Never directed towards a student of color (that I’ve been told yet), but still being casually used in conversation.” — MIDDLE SCHOOL TEACHER, INDIANA

“The slurs have been written on assignments. ‘Send the Muslims back because they are responsible for 9/11.’” — HIGH SCHOOL TEACHER, MINNESOTA

"’I hate Muslims.’ (Student blurted this while the class was learning about major religions.)” — MIDDLE SCHOOL TEACHER, WASHINGTON

“I’ve had a lot of students repeat the phrase ‘Trump that bitch’ in my class, and make jokes about Hispanic students ‘going back to Mexico.’” — HIGH SCHOOL TEACHER, GEORGIA

“A proud proclamation of racism was made by a student after the election: ‘Bet those black people are really scared now.’” — HIGH SCHOOL TEACHER, MICHIGAN

“White males have been overheard saying, ‘screw women’s rights, fag lover liberal, build the wall, lock her up.’ The rebel flag is draped on the truck of a popular student, and the p-word has been used very casually, citing Trump as the excuse.” — HIGH SCHOOL TEACHER, MICHIGAN

“Kids saying, ‘Trump won, you’re going back to Mexico!’ Boys grabbing girls, cornering girls against lockers. Kids yelling, ‘Trump won, so [there will] be less people here soon.’” — HIGH SCHOOL TEACHER, KANSAS

“Today I photographed vandalism in the boy’s bathroom that mentioned a specific black student (1 of 7 in a school of 200). It repeatedly mentioned the KKK, used the n-word and joining Jews. A student drew a swastika on my board a few days ago. A black female ran out of a room crying after being racially harassed by multiple students during two different classes. One student … reported asking two different Latina students if they were ready to move back to Mexico now that Trump is president. I have witnessed an increase in racist and sexist jokes by students who support Trump. I personally spent most of the day putting out fires related to these issues, including documenting and reporting them. Multiple white males also expressed anger over the school wanting to post signs stating we are a sanctuary school.” — HIGH SCHOOL TEACHER, OREGON

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Should kids play football? No.

In this excerpt from the Dana Foundation's blog post by Dr. Guy McKhann, he looks at the choice faced by parents regarding letting their kids play football. We cover this topic in our new book, Healing the Brain.


“Don’t Let Kids Play Football” is the title of a New York Times OpEd column by Bennet Omalu. Dr. Omalu gets credit for being the first to recognize the distinctive neuropathology associated with repeated head injuries in an NFL player. Omalu was on call when an autopsy was needed for former Pittsburgh Steeler Mike Webster.

Not being a football fan, Omalu was one of the few adult males in Pittsburgh unfamiliar with Webster, a star center for 17 seasons. Some time after Webster’s retirement in 1990, he gradually began to deteriorate mentally, first with depression and paranoia, then gradual loss of cognition, so that at the time of his death, he was essentially demented. Because of his football notoriety, his troubles were documented in the local newspapers.

Omalu realized that he was seeing a very unique pathology. The gross brain appeared normal, but when he cut into it and made stained sections, he noted the marked accumulation of the protein tau. Tau, in the form of tangles, is one of the hallmarks of Alzheimer’s disease, as is the accumulation of another protein, beta amyloid, in the form of plaques. In Webster’s brain there were very few amyloid-containing plaques and the tau accumulation was in a different distribution than what one would see with Alzheimer’s. Omalu and his colleagues published two papers in the journal Neurosurgery: one on Webster and another on fellow Steeler Terry Long. They described their findings, suggesting that repeated head injuries might be associated with this pathology. All hell broke loose. The NFL powers that be were not happy that their sport might be associated with brain damage. Several physicians involved with NFL teams wrote the journal asking that the papers be withdrawn. (Withdrawing a paper rarely happens, and is done when there is clear misconduct such as fraud). The papers were not withdrawn.

Deciding that challenging the powerful NFL was an impossible task, Omalu left Pittsburgh and became a medical examiner in California, out of the limelight. However, Dr. Ann McKee, a well-regarded neuropathologist in Boston, picked up the slack and let the world know she and her colleagues were available to do the neuropathology on athletes, and military personnel, with head injuries. She was joined by a neurosurgeon, Robert Cantu, and Chris Nowinski, a former Harvard football player and professional wrestler, who became concerned about his own history of head injuries. Chris has become the liaison between the Boston investigators and the athletic world, active in obtaining permission and access for the Boston group to do autopsies.

As of September 2015, they’ve analyzed the brains of 91 former NFL players and found the distinctive pathology in 87 (96 percent).

The clinical course in the others is much like that of Mike Webster: exposure to a series of head injuries over years, a period of normal functioning after retirement, and gradual decline in cognitive functions. What’s going on in these brains? We really don’t know. However, one possibility is that the accumulation of tau is initiated by head trauma. Even after the trauma stops, the accumulation continues until tau reaches a level that is toxic to nerve cells. This process may take years and might be exacerbated by the person’s use of alcohol or drugs.

So should kids play football? I have nine grandchildren. My youngest, twin seven-year-old boys, are into gymnastics and swimming, so they’re not at risk of head injuries (though they enjoy pummeling each other). The others are into soccer, lacrosse, mountain climbing, and cross country skiing. What would I tell them? I think that there is a lot of hand-waving about the susceptibility of the developing brain. In some instances the younger brain is more resistant to injury. An eight-year-old can survive and make a remarkable recovery from a stroke, while a similar stroke in an 80-year-old would be devastating. However a diffuse injury (one that is spread more widely), associated with a head injury, may have effects on brain development.
I don’t know where to draw the line regarding age. I suggest that prior to age 18 kids play less violent forms of football, like touch or flag football, to significantly reduce the chance of head injury.

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Just What Do Drugs Specifically Do to Your Brain?

The old image was of eggs on a frying pan. But drugs, from alcohol to nicotine to meth and heroin target specific areas of the brain, and thus have varying effects on us and our behavior, short- and long-term.From our new book: Healing the Brain:
 

The brain, this three-pound mass of gray and white matter, sits at the center of all human activity—you need it to drive a car, to enjoy a meal, to breathe, to create an artistic masterpiece, and to enjoy everyday activities. In brief, the brain regulates your body’s basic functions; enables you to interpret and respond to everything you experience; and shapes your thoughts, emotions, and behavior.

The brain is made up of many parts that all work together as a team. Different parts of the brain are responsible for coordinating and performing specific functions. Drugs can alter important brain areas that are necessary for life-sustaining functions and can drive the compulsive drug abuse that marks addiction.

Key brain areas affected by drug abuse include:

The brain stem, which controls basic functions critical to life, such as heart rate, breathing, and sleeping.

The cerebral cortex, which is divided into areas that control specific functions.

Different areas process information from our senses, enabling us to see, feel, hear, and taste. The front part of the cortex, the frontal cortex or forebrain, is the thinking center of the brain; it powers our ability to think, plan, solve problems, and make decisions.

The limbic system, which contains the brain’s reward circuit. It links together a number of brain structures that control and regulate our ability to feel pleasure. Feeling pleasure motivates us to repeat behaviors that are critical to our existence. The limbic system is activated by healthy, life-sustaining activities such as eating and socializing— but it is also activated by drugs of abuse. In addition, the limbic system is responsible for our perception of other emotions, both positive and negative, which explains the mood-altering properties of many drugs.

How do drugs work in the brain?

Drugs are chemicals that affect the brain by tapping into its communication system and interfering with the way neurons normally send, receive, and process information. Some drugs, such as marijuana and heroin, can activate neurons because their chemical structure mimics that of a natural neurotransmitter. This similarity in structure “fools” receptors and allows the drugs to attach onto and activate the neurons. Although these drugs mimic the brain’s own chemicals, they don’t activate neurons in the same way as a natural neurotransmitter, and they lead to abnormal messages being transmitted through the network.

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When are we MOST at-risk for getting addicted?

A friend said to me that the only way he'll get through watching election returns is to have a few drinks of wine. Seems benign, but what times in our lives make us most vulnerable for drug use? Here's an excerpt from our new book, Healing the Brain:

Risk of drug abuse increases greatly during times of transition.

For an adult, a divorce or loss of a job may lead to drug abuse; for a teenager, risky times include moving or changing schools. In early adolescence, when children advance from elementary through middle school, they face new and challenging social and academic situations. Often during this period, children are exposed to abusable substances such as cigarettes and alcohol for the first time. When they enter high school, teens may encounter greater availability of drugs, drug use by older teens, and social activities where drugs are used.

At the same time, many behaviors that are a normal aspect of their development, such as the desire to try new things or take greater risks, may increase teen tendencies to experiment with drugs.

Some teens may give in to the urging of drug-using friends to share the experience with them. Others may think that taking drugs (such as steroids) will improve their appearance or their athletic performance or that abusing substances such as alcohol or MDMA (ecstasy or “Molly”) will ease their anxiety in social situations. A growing number of teens are abusing prescription ADHD stimulants such as Adderall® to help them study or lose weight. Teens’ still-developing judgment and decision-making skills may limit their ability to accurately assess the risks of all of these forms of drug use. Using abusable substances at this age can disrupt brain function in areas critical to motivation, memory, learning, judgment, and behavior control.  

So, it is not surprising that teens who use alcohol and other drugs often have family and social problems, poor academic performance, health-related problems (including mental health), and involvement with the juvenile justice system.

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