Showing posts with label fentanyl. Show all posts
Showing posts with label fentanyl. Show all posts

Sunday, June 1, 2025

Pain and Chronic Pain--New!

New!

I think you might like this book – "Healing the Brain, Second Edition: Pain and Chronic Pain" by David Balog.

Start reading it for free: 

https://a.co/2ilcGHE

Sample pages;




Start reading it for free: 

https://a.co/2ilcGHE




Start reading it for free: 

https://a.co/2ilcGHE



Friday, March 2, 2018

Pain, Chronic Pain, and Opioids

Pain: What is it and how do you treat it?

Chronic pain is recognized by the World Health Organization as a leading medical issue, worldwide.

Pain also has been called a first possible step on the road to opioid addiction. A slip, a broken limb followed by a prescription to oxycontin or other powerful opioid, misuse of that prescription, and the path to heroin or fentanyl abuse can easily start.
Learn about the brain. Click here.

Pain is an unpleasant sensation and emotional experience linked to tissue damage. Its purpose is to allow the body to react and prevent further tissue damage.

We feel pain when a signal is sent through nerve fibers to the brain for interpretation.

The experience of pain is different for everyone, and there are different ways of feeling and describing pain. This can makes it difficult to define and treat.

Pain can be short-term or long-term, it can stay in one place, or it can spread around the body.

Fast facts on pain:

--Pain results from tissue damage.
--It is a part of the body's defense mechanism. --It warns us to take action to prevent further tissue damage.
--People experience and describe pain differently, and this makes it hard to diagnose.
--A range of medications and other treatments can help relieve pain, depending on the cause.

Pain chronic, acute

Pain can be chronic or acute and take a variety of forms and severities.


Pain is felt when special nerves that detect tissue damage send signals to transmit information about the damage along the spinal cord to the brain. These nerves are known as nociceptors.

The brain then decides what to do about the pain.

For example, if you touch a hot surface, a message will travel through a reflex arc in the spinal cord and cause an immediate contraction of the muscles. This contraction will pull your hand away from the hot surface.

This happens so fast that the message doesn't even reach the brain. However, the pain message will continue to the brain. Once there, it will cause an unpleasant sensation of pain to be felt.

How an individual's brain interprets these signals and the efficiency of the communication channel between the nociceptors and the brain dictate how people feel pain.

Source: Medical News Today
By Adam Felman   
Reviewed by Deborah Weatherspoon, PhD, RN, CRNA

Thursday, December 21, 2017

Opioid crisis cuts U.S. life expectancy

Opioid crisis trims U.S. life expectancy
The opioid crisis is rippling through the U.S. healthcare system, causing a spike in rates of hepatitis C related to increased opioid injections and reducing overall life expectancy among Americans, which has fallen for the second year in a row, U.S. health officials said.

Addiction is a brain disease. Learn about it in clear language.

Heroin, an illegal opioid that is typically injected, accounted for around 15,500 deaths, and prescription painkillers were involved in about 14,500, the CDC reported.
“These are not simply numbers - these are actual lives,” said Benjamin F. Miller, chief policy officer of Well Being Trust, a non-profit foundation focused on mental health issues. “Seeing the loss of life at this dramatic rate calls for more immediate action.”
President Donald Trump in October declared the opioid crisis a public health emergency, which senior administration officials said would redirect federal resources and loosen regulations to combat abuse of the drugs. However, he stopped short of declaring a national emergency, a move he had promised months before and which would have freed up more federal money.
Overdose rates rose in 40 states and in Washington, D.C., between 2015 and 2016, with 17 states seeing increases of 25 percent or more, according to the TFAH analysis.
“Every community has been impacted by this crisis,” Auerbach said, adding that the government was not making the investments needed to “turn the tide.”
The surge in overdose deaths has depressed recent gains in U.S. life expectancy, which fell to an average age of 78.6, down 0.1 year from 2015 and marking the first two-year drop since 1962-1963.
In a separate report, the CDC linked the recent steep increases in hepatitis C infections to increases in opioid injection.
Researchers used a national database that tracks substance abuse admissions to treatment facilities in all 50 U.S. states. They found a 133 percent increase in acute hepatitis C cases that coincided with a 93 percent increase in admissions for opioid injection between 2004 to 2014.
“Hepatitis C is a deadly, common, and often invisible result of America’s opioid crisis,” said Dr. Jonathan Mermin, director of CDC’s National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention. Mermin urged testing people who inject drugs for hepatitis C infection to prevent new transmissions.
As the opioid epidemic has worsened, many state attorneys general have sued makers of these drugs as they investigate whether manufacturers and distributors engaged in unlawful marketing behavior.
Reuters, Inc.


Thursday, December 7, 2017

Chronic pain: An unwanted memory


The brain, in easy-to-read language.
Dr. Allan Basbaum, pain specialist, called chronic pain a memory...one we don't want. Yet pretreatment of pain in the 1990s with drugs such as oxycontin has, many say, led to our current addiction crisis with opioids, including heroin and fentanyl.

Pain Management

YESTERDAY

  • Early Greeks and Romans advanced the idea that the brain played a role in producing the perception of pain.
  • In the 19th century, physician-scientists discovered that opiates such as morphine could relieve pain and chemist Felix Hoffmann developed aspirin from a substance in willow bark. Aspirin remains the most commonly used pain reliever.
  • The French physician, Dr. Albert Schweitzer, proclaimed in 1931 that, “Pain is a more terrible lord of mankind than even death itself.”
  • In 1994, the International Association for the Study of Pain (IASP) (http://www.iasp-pain.org/) defined pain as an “unpleasant sensory and emotional experience associated with actual or potential tissue damage.”

TODAY

  • Pain affects more Americans than diabetes, heart disease and cancer combined.
  • Pain is cited as the most common reason Americans access the health care system. It is a leading cause of disability and it is a major contributor to health care costs.
  • According to the National Center for Health Statistics (2006), approximately 76.2 million, one in every four Americans, have suffered from pain that lasts longer than 24 hours and millions more suffer from acute pain.
  • Chronic pain is the most common cause of long-term disability.
  • The diversity of pain conditions requires a diversity of research and treatment approaches.
  • Pain can be a chronic disease, a barrier to cancer treatment, and can occur alongside other diseases and conditions (e.g. depression, post-traumatic stress disorder, traumatic brain injury).
  • For infants and children, pain requires special attention, particularly because they are not always able to describe the type, degree, or location of pain they are experiencing.
  • Discoveries of differences in pain perceptions and responses to treatment by gender has have led to new directions for research on the experience and relief of pain. For example, medications called kappa-opioids provide good relief from acute pain in women, yet increase pain in men.
  • NIH-supported scientists identified a gene variant of an enzyme that reduces sensitivity to acute pain and decreases the risk of chronic pain.
  • COX-2 (cyclooxygenase-2) is a major contributor to pain associated with inflammation. A study of genes affected by COX-2 led to the discovery of its role in connection to multiple cellular pathways that contribute to pain relief and adverse side-effects.
  • Behavioral interventions for pain also demonstrate promise for providing pain relief either in conjunction with or in lieu of drug interventions. For example, NIH-supported research has demonstrated that individualized pain management programs may reduce cancer pain for some patients.

TOMORROW

The NIH is poised to make major discoveries that will improve health outcomes for individuals experiencing acute or chronic pain by applying opportunities in genomics and other technologies to improve our understanding of the fundamental causes of pain. This will be accomplished through translating basic laboratory science to new, improved pain treatments and by providing strategic support for the research community to discover more effective pain treatment strategies.

Applying genomics and other technologies to understand pain. Advances in basic and clinical genetics are making it possible to both characterize genetic factors related to pain sensitivity and develop novel therapeutic approaches.

  • In ongoing pain studies, scientists are using technologies such as microarray-based assays (complex genetic and molecular tests) to better understand the mechanisms of pain and analgesia, identify new targets for analgesic drugs, and test the efficacy and adverse reactions of newly developed or currently used drugs to treat pain. Researchers are currently using these technologies to discover the mechanisms by which drugs such as COX-inhibitors and neurotropins may relieve pain.
Translating basic science to improved pain treatments. Researchers will continue to focus on advancing both biological and behavioral pain management strategies from the research sphere to clinical applications.

  • Innovative ways to categorize and measure pain are currently being studied. For example, scientists are using computer-assisted technology to develop a novel program that will capture and quantify pain experiences. Tools such as this will be combined with existing methods to more accurately and consistently measure pain over time and across groups, diseases, and conditions.
  • Research will continue identifying biomarkers and biological pathways associated with painful conditions resulting from the use of drugs to treat diseases such as cancer and HIV/AIDS (http://www.umgcc.org/research/et.htm).
Providing Strategic Support for Research into Pain Treatment Strategies.

  • The NIH Pain Consortium (http://painconsortium.nih.gov/), an effort involving over 21 NIH Institutes, Centers, and Offices, promotes collaboration among the various NIH programs that support pain research, and provides strategic direction for accelerating advances in pain prevention, and treatment.
  • The Patient Protection and Affordable Care Act has established an Interagency Pain Research Coordinating Committee, led by the Department of Health and Human Services, to assess and coordinate pain research efforts across the Federal government.
Contact: NINR Office of Science Policy and Public Liaison, info@ninr.nih.gov, 301-496-0207

National Institute of Nursing Research (NINR): 
http://www.ninr.nih.gov/


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Sunday, July 16, 2017

Join our conversation on the drug epidemic and families



Image showing lethal doses of Heroin and Fentanyl

The amount of drug that can kill. Fentanyl threatens to greatly worsen our addiction crisis.


















A social worker in a small upstate New York town told me that in order to shoot up with meth, teens in his town used the only private space they could find: their family car. They shot up in the most secluded place they could find--empty downtown areas, WHILE DRIVING.

A mental health worker in Vermont told me that they're on the verge of giving up on today's youth and trying to prevent children from becoming the next generation of addicts.


Doctors in emergency rooms give families devastating news about their children, anywhere from the limited, compromised futures they face to the crushing news of their deaths.
 
Former President Bill Clinton gave a speech recently saying that the opioid epidemic will destroy this country.

WHAT WE'RE DOING

A Thousand Moms, which has produced a series of books entitled "Healing the Brain," will hold a four-week conference-call series entitled "Network of Support: Addiction and Our Families." 


Made possible by a donation from a concerned supporter, A Thousand Moms’ four-part information series for educators, parents, social workers, other concerned individuals is now free of charge. Dates for Network of Support: The Addiction Crisis are Tuesdays, July 18/19, July 25/26, August 1/2 and August 8/9. (Original presentations are repeated on the following day for the convenience of participants. Times: Tuesdays at 11:00 am EDT., Wednesdays at 7:00 pm EDT. 
Calls last one hour. CONF CALL #: 605 475-6333  ACCESS CODE: 2456474

Presented in clear, non-complicated language

To empower participants, coverage in this series will include a basic understanding of how addiction works in the brain and body. Each session will combine addiction facts with practical strategies for coping with current or potential substance abuse by a loved one. Substance abuse topics include: How the brain works; Why is addiction a brain disease? Opioids/heroin;  Methamphetamines, cocaine; and Alcohol and marijuana. Support topics include: Positive parenting as a prevention tool for drug abuse; Communication, encouragement,and negotiations; Setting limits; supervision, and knowing your child's friends. 
The conference call programs are presented by Fred Elia, MS, president of A Thousand Moms, and David Balog, author, Dana Foundation’s Sourcebook of Brain Science and Healing the Brain: Stress, Trauma and Development.
First call: Tuesday, July 18, 11:00 AM EDT
CONF CALL #: 605 475-6333  ACCESS CODE: 2456474 


Wednesday, May 24, 2017

Opioids, Heroin and Public Health

In this blog we will look at timely topics on the brain. Learn along with a copy from our book series, Healing the Brain. Get your copy today. A Thousand Moms offers workshops to the general public. These workshops are presented in clear, non-complicated language. In New York, Vermont and Massachusetts, please call 518 322-0607 or write to athousandmoms@yahoo.com.


Source: The Dana Foundation

The Opioid Epidemic

“We’ve moved from an epidemic to a crisis” in opioid abuse in the United States, said Daniel Ciccarone, M.D., MPH, during a panel discussion at AAAS in Washington, DC, this week. Ciccarone, a doctor at University of California, San Francisco, who treats addicted people and does research, described a pattern of intertwined waves involving abuse of prescription pills, heroin, and synthetic opioids like fentanyl.

For example, while overdose deaths due to prescription pill use are spread relatively evenly across the country, “this is not true for heroin,” Ciccarone said. The Northeast has had troubles with opioid abuse for a generation, while in the Midwest, numbers have jumped just recently. And while older folks (50-64) are using pills in greater numbers, it’s younger people (20-35) driving heroin use.
“Heroin itself is becoming more and more dangerous,” he said, especially when it is laced with synthetic drugs like fentanyl and carfentanil (used to tranquilize elephants). People who stop breathing after using these stronger concoctions often don’t respond to emergency treatments like naloxone.


The latest epidemic came about in large part out of doctors’ good intentions, said Nora Volkow, M.D., director of the National Institute on Drug Abuse, part of NIH. Starting in the late 1990s, doctors increasingly prescribed opioids to young and old for acute (sudden onset) and chronic pain (pain that is regular and has lasted for months). They were responding to a call to better help people who were in severe pain, and they thought that while the patient was experiencing pain, they would not be likely to become addicted to the drug.

“The epidemic really started from our over-prescription,” said Volkow, a member of the Dana Alliance for Brain Initiatives. For example, in 2013, the number of total pills prescribed in this country was the equivalent of a 1 month supply for every adult in the US, she said. Over the past 15 years, “the whole United States appeared to become infected,” she said.

Opioids are very effective for acute pain. Volkow described her own experience taking them after she was in a car accident: “It was amazing, not just because the pain was gone but because of that great sense of well-being.” But many people grow more tolerant of the drug the longer they use it, and need ever-increasing doses to find relief. This can lead to over-use, and to people transitioning from pills to black-market drugs like heroin and fentanyl. “80 percent of new cases of heroin are actually emerging from individuals who became addicted to prescription opioids,” she said; because prescription drugs are expensive and difficult to get, while heroin has gotten cheaper, they make the switch. (The other 20 percent of new users are mainly younger people, who started directly with heroin as a recreational drug.)

This is dire news, but we have experienced waves of other deadly maladies and overcome them before. “When we had the HIV epidemic, when we had the Ebola epidemic, we addressed it using science,” Volkow said. “Scientific solutions can provide us means to control these problems, and it’s not any different for the opioid crisis”

For example, Karen Drexler, M.D., an addiction psychiatrist and program director for addictive disorders at the Veterans Healthcare Administration (VA), described the success of Dr. John Snow in solving a cholera epidemic in 1854 London. While others blamed bad air for the outbreak, Snow looked at this map showing where the sickened people lived, and asked what they had in common. It turned out they all obtained water from one local pump. Snow stopped the outbreak by taking the handle off the pump. People obtained their water from elsewhere, and stopped getting sick.
opioid_map_2013
Map of opioid prescriptions and overdoses. Data source: National Vital Statistics, 2013 Source: State of Maryland

Looking at “our ‘map of London’ for the opioid epidemic,” Drexler said, it was clear that the most overdoses were where there were the most over-prescriptions. For opioids, “taking the handle off the pump” means reducing the number of prescriptions and changing prescription advice to use the lowest effective dose for the shortest amount of time so people have the least risk of becoming addicted. “Prevention is best,” she said.

The VA is applying a series of evidence-based actions to reduce prescriptions, including more-closely monitoring people who are taking opioids, advising doctors not to prescribe opioids for chronic pain, and suggesting alternative drugs and counseling.

Volkow described three areas NIH and others are working on: developing better, safer treatments for chronic pain; designing better strategies to help addicted people come off the drugs; and finding more direct opioid-blocking drug interventions like methadone, naloxone, and buprenorphine. The latter are proven to help, but “they are not being used. Less than 15 percent of people who would benefit from these are getting them,” she said, because of stigma, lack of doctor training, and lack of insurance reimbursement. In addition, “with science, of course we look for transformation,” she said, including looking for a potential vaccine against fentanyl.

Drexler described several current models of treatment that have evidence of success, including brief one-on-one counseling, which “is sufficient for many with opioid-use disorder,” she said. Other methods include the Massachusetts model of buprenorphine maintenance, Project Echo in New Mexico, and a method mirroring the alcohol care management model.

“I’m very hopeful that we’ll be able to disseminate these models out,” she said, perhaps by using marketing methods similar to those drug companies use. Still, “we need more help for newer, better treatments as well as how to implement the ones we have.”

“We need to treat this as a poisoning epidemic, not a drug epidemic,” Ciccarone said, including boosting programs that do “harm reduction,” caring for people who are engaging in risky behavior. “We tend to think of harm reduction as ‘aiding and abetting drug users,’ in the political sphere, but harm reduction saves lives,” it’s cost-effective, and it can bring people into treatment, he said. “Stop treating the drugs as sort of the special privilege of the criminal justice folks and the injured bodies as only public health.”