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Source: The Dana Foundation
The Opioid Epidemic
“We’ve moved from an epidemic to a crisis” in opioid abuse in the United States, said
Daniel Ciccarone,
M.D., MPH, during a panel discussion at AAAS in Washington, DC, this
week. Ciccarone, a doctor at University of California, San Francisco,
who treats addicted people and does research, described a pattern of
intertwined waves involving abuse of prescription pills, heroin, and
synthetic opioids like fentanyl.
For example, while overdose deaths due to prescription pill use are
spread relatively evenly across the country, “this is not true for
heroin,” Ciccarone said. The Northeast has had troubles with opioid
abuse for a generation, while in the Midwest, numbers have jumped just
recently. And while older folks (50-64) are using pills in greater
numbers, it’s younger people (20-35) driving heroin use.
“Heroin itself is becoming more and more dangerous,” he said,
especially when it is laced with synthetic drugs like fentanyl and
carfentanil (used to tranquilize elephants). People who stop breathing
after using these stronger concoctions often don’t respond to emergency
treatments like naloxone.
The latest epidemic came about in large part out of doctors’ good intentions, said
Nora Volkow,
M.D., director of the National Institute on Drug Abuse, part of NIH.
Starting in the late 1990s, doctors increasingly prescribed opioids to
young and old for acute (sudden onset) and chronic pain (pain that is
regular and has lasted for months). They were responding to a call to
better help people who were in severe pain, and they thought that while
the patient was experiencing pain, they would not be likely to become
addicted to the drug.
“The epidemic really started from our over-prescription,” said
Volkow, a member of the Dana Alliance for Brain Initiatives. For
example, in 2013, the number of total pills prescribed in this country
was the equivalent of a 1 month supply for every adult in the US, she
said. Over the past 15 years, “the whole United States appeared to
become infected,” she said.
Opioids are very effective for acute pain. Volkow described her own
experience taking them after she was in a car accident: “It was amazing,
not just because the pain was gone but because of that great sense of
well-being.” But many people grow more tolerant of the drug the longer
they use it, and need ever-increasing doses to find relief. This can
lead to over-use, and to people transitioning from pills to black-market
drugs like heroin and fentanyl. “80 percent of new cases of heroin are
actually emerging from individuals who became addicted to prescription
opioids,” she said; because prescription drugs are expensive and
difficult to get, while heroin has gotten cheaper, they make the switch.
(The other 20 percent of new users are mainly younger people, who
started directly with heroin as a recreational drug.)
This is dire news, but we have experienced waves of other deadly
maladies and overcome them before. “When we had the HIV epidemic, when
we had the Ebola epidemic, we addressed it using science,” Volkow said.
“Scientific solutions can provide us means to control these problems,
and it’s not any different for the opioid crisis”
For example, Karen Drexler, M.D., an addiction psychiatrist and
program director for addictive disorders at the Veterans Healthcare
Administration (VA), described the success of Dr. John Snow in solving a
cholera epidemic in 1854 London. While others blamed bad air for the
outbreak, Snow looked at this map showing where the sickened people
lived, and asked what they had in common. It turned out they all
obtained water from one local pump. Snow stopped the outbreak by taking
the handle off the pump. People obtained their water from elsewhere, and
stopped getting sick.
Map of opioid prescriptions and overdoses. Data source: National Vital Statistics, 2013 Source: State of Maryland
Looking at “our ‘map of London’ for the opioid epidemic,” Drexler
said, it was clear that the most overdoses were where there were the
most over-prescriptions. For opioids, “taking the handle off the pump”
means reducing the number of prescriptions and changing prescription
advice to use the lowest effective dose for the shortest amount of time
so people have the least risk of becoming addicted. “Prevention is
best,” she said.
The VA is applying a series of evidence-based actions to reduce
prescriptions, including more-closely monitoring people who are taking
opioids, advising doctors not to prescribe opioids for chronic pain, and
suggesting alternative drugs and counseling.
Volkow described three areas NIH and others are working on:
developing better, safer treatments for chronic pain; designing better
strategies to help addicted people come off the drugs; and finding more
direct opioid-blocking drug interventions like methadone, naloxone, and
buprenorphine. The latter are proven to help, but “they are not being
used. Less than 15 percent of people who would benefit from these are
getting them,” she said, because of stigma, lack of doctor training, and
lack of insurance reimbursement. In addition, “with science, of course
we look for transformation,” she said, including looking for a potential
vaccine against fentanyl.
Drexler described several current models of treatment that have
evidence of success, including brief one-on-one counseling, which “is
sufficient for many with opioid-use disorder,” she said. Other methods
include the Massachusetts model of buprenorphine maintenance,
Project Echo in New Mexico, and a method mirroring the alcohol care management model.
“I’m very hopeful that we’ll be able to disseminate these models
out,” she said, perhaps by using marketing methods similar to those drug
companies use. Still, “we need more help for newer, better treatments
as well as how to implement the ones we have.”
“We need to treat this as a poisoning epidemic, not a drug epidemic,”
Ciccarone said, including boosting programs that do “harm reduction,”
caring for people who are engaging in risky behavior. “We tend to think
of harm reduction as ‘aiding and abetting drug users,’ in the political
sphere, but harm reduction saves lives,” it’s cost-effective, and it can
bring people into treatment, he said. “Stop treating the drugs as sort
of the special privilege of the criminal justice folks and the injured
bodies as only public health.”